STUDY THE RELATIONS BETWEEN ANGIOPOIETIN-LIKE PROTEIN 4 (ANGPTL4) AND LIPOPROTEIN LIPASE AS PREDICTORS FOR ISCHEMIC HEART DISEASE IN PATIENTS WITH T2DM
Betatrophin production and blood lipid profile have been proven in previous research to have a correlation, both in the laboratory and in clinical settings. Investigations on the connection and contact behavior of lipoprotein lipase, betatrophin, and angiogenin- likeprotein3 (ANGPTL3) continue to vary from one another (LPL). This study aimed to evaluating the relationship between betatrophin, ANGPTL4, and LPL in addition to the severity of IHD in individuals with diabetes. There were sixty people with diabetes in the case group (30 with IHD and 30 without IHD). The control group included thirty people in total. While the serum concentration of ANGPTL4 was assessed using a double antibody sandwich ELISA, the serum concentrations of betatrophin, LPL, and ANGPTL4 were assessed using the enzyme-linked immunosorbent assay (ELISA). The levels of total cholesterol, fasting blood glucose, and triglycerides in each group were determined using an automated biochemical analyzer. The clinical baseline data for each patient group was incorporated into the analysis within the same time frame. Consequently, compared to diabetic patients without IHD and those in the control group, individuals with IHD had significantly higher levels of betatrophin, ANGPTL4 and LPL (p 0.05). With diabetic patients with IHD, the Gensini rating significantly and favorably correlated with TC, TG, LDL-C, betatrophin, LPL, and BMI (r = 0.201, 0.501, 0.045, 0.562, 0.611, and 0.431 and P = 0.041, 0.008, 0.038, 0.009, 0.002, and 0.039 respectively). In all groups of gensini score with (P<0.05), there is a statistically significant difference found in the levels of betatrophin, ANGPTL4, and LPL. In patients with diabetes, the degree of IHD was associated with the betatrophin, ANGPTL4, and LPL parameters.
Keywords: Angiopoietin-like protein 4, Lipoprotein lipase, Diabetes mellitus, Ischemic heart disease