STUDY THE ANTIMICROBIAL ACTIVITY OF TOPICAL GEL FORMULATION OF “ERYTHROMYCIN AND DEXAMETHASONE” IN VITRO & IN VIVO
The present study focused on antimicrobial activity of a combined topical veterinary medicinal formulation of erythromycin ethyl succinate with dexamethasone for treatment skin infections, otitis, ocular infections and infectious wounds. In vitro, gel formula result showed good antibacterial activity with high stability after storage at (30-40) °C for 6 months. In vivo, formulated gel has shown a significant effectiveness promoting faster wound healing in lab animals (albino mice) and that result combined with histopathological view. Gel formula acts as a scaffold biomaterial for wound closure besides, antibacterial effective role that represent a promising strategy to increase the effective of erythromycin as topical delivery drug. The present study suggests that erythromycin gel is stable, safe, provides remarkable antibacterial susceptibility, reduces pain and wound recovery.
Keywords: Antimicrobial activity, Erythromycin, Dexamethasone, Gel formula.