PREPARING AND CHARACTERIZING SOME NEW DERIVATIVES OF ORGANIC CYCLIC COMPOUNDS DERIVED FROM SOME DRUGS AND STUDYING THEIR BIOLOGICAL ACTIVITY
This study involved synthesis some of derivatives via that a Suzuki-Miyaura cross-coupling procedure was used in order to produce a wide variety of Baclofen derivatives. After beginning with the reaction of 4-methoxy carbonyl phenyl boronic acid by the use of the reflex method, the treatment of Baclofen with a number of other boronic acids was carried out. The subsequent stage was the incorporation of Pd(0)(PPh3)4, and lastly, once the reaction had reached a state of equilibrium,Ethyl Acetoacetate ( EtOAc) was incorporated into the mixture. Taking this action was necessary in order to finish the procedure. Using the thin layer chromatography (TLC)technique, the observation of the reaction was carried out in order to carry out the observation. In order to accomplish the job of characterizing all of the unique Baclofen derivatives that were discussed in the preceding paragraphs [1-6], the analytical procedures of Fourier Transform Infrared (FT-IR) , Proton nuclear magnetic resonance (1HNMR) ,Carbon-13 nuclear magnetic resonance (13C-NMR) , and C.H.N were used. Furthermore, a wide range of other physical characteristics, such as color, Rf, and mechanical capabilities, were investigated and appraised. The objective of the experiment was to determine whether or not the treatment was effective against two different types of bacteria according to the biological standards. One of the objectives of the experiment was to do this. There was one species of fungus, which was Candida albicans, and one of the bacteria was positive (Staphylococcus aureus). The other bacterium was negative (Escherichia coli), and there was one type of bacteria. Of the bacteria, two were found to be positive. Following the assessment of the compounds' bacterial inhibitory biological activity [1-6], it was shown that the derivatives had an exceptionally high degree of effectiveness at a certain concentration. An additional accomplishment was the successful completion of a molecular docking investigation of novel Baclofen derivatives. [1-6].
Keywords: Heterocycli compounds, Baclofen, Suzuki reaction.