HYPOGLYCAEMIC AND ANTIHPERGLYCAEMIC ACTIITIES OF AQUEOUS EXTRACT OF FICUS CARICA IN DIABETIC RATS
The Ficus carica ( fig ) is an important harvest worldwide for its dry and fresh consumption. Its common edible part is the fruit which is fleshy, hollow, and receptacle . The dried fruits of Ficus carica have been reported as an important source of vitamins, minerals, carbohydrates, sugars, organic acids, and phenolic compounds A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the aqueous leave extract by oral glucose tolerance test (OGTT) , normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide in a dose of 120 mg kg induced non insulin-dependent diabetes mellitus Wister albino rats. Graded doses (250 and 500 mg/kg) of the aqueous leave extract suspended in gum acacia were administered to normal and experimental diabetic Wister albino rats. Effect on glucose tolerance test showed a significant reduction in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide. Also the extract showed a high LD50 value and could be used safetly.
Keywords: Ficus Carica (L) ; (Fig ) ; Antidiabetic Activity; Streptozotocin; Nicotinamide; Rats.