Year:2022   Volume: 4   Issue: 3   Area:

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Tiba Idham MOHAMMED

EVALUATION OF THE OPTIMAL KI-67 CUTOFF VALUE DETERMINING ‎GRADES OF GLIOMA IN TURKISH POPULATION

Gliomas are a heterogenous group of malignancies, occupying nearly 80% of central nervous system ‎‎(CNS) primary malignant tumors and rank the first among brain tumors. The Ki-67 is a routinely ‎assessed protein in the pathological study of a tumor. It’s widely investigated as a proliferation ‎marker throughout the literature for its prognostic, predictive and therapeutic roles. A local Turkish ‎cohort of 102 patient in the Medical Park/ Goztepe, Bahcesehir university, were enrolled in this ‎retrospective study, to identify a precise cut point of ki-67 protein level, separates between glioma ‎WHO assigned grades, and to explore the possible predictive relationship between Ki-67 ‎proliferation index and the preoperatively levels of differential white blood cells in series of archival ‎adult malignant gliomas with grade II, III and IV lesions. The statistical tests revealed that ki-67 ‎expression level of 9.5% is a significant cutoff value between grade IV Glioblastoma and grade II ‎and III astrocytic and oligodendroglia gliomas. And according to the findings, Age and ‎preoperatively measured Monocyte’s count showed a statistical difference between patients with ‎low (<10%) and high (≥10%) expression of ki-67. Thereby, result reinforces the statement that Ki-‎‎67 is in proportion to the glioma histologic malignancy degree and is a good tool for assigning ‎grading between GBM and non-GBM gliomas. Hence, encouraging that ki-67 is a potent candidate ‎in development of new classification system combining morphological, molecular and genetic ‎features to better diagnose and treat glial malignant tumors. ‎

Keywords: Ki-67, Grading, GBM, Glioma, Cutoff, Turkey

http://dx.doi.org/10.47832/2717-8234.12.52


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