ASSESSMENT OF CALCIUM LEVELS IN PARATHYROID DISTURBANCES IN MATURE MALE RABBITS
In rabbits, the absorption of calcium is directly correlated with the quantity consumed in the meal, rather than being regulated based on metabolic requirements, and absorption of calcium is relatively-independent from vitamin D3 so this research aims to assist calcium levels in parathyroid gland disorders in rabbits. Fifty mature-male-rabbits were randomly assigned into 5 groups, (10 rabbits/group); Group-1:(Control) was intraperitoneal (I/P) injected normal saline (one ml /kg /day for forty five days). Group-2: (Hyperparathyroidism); was IP injected with Lithium Chloride (72mg/kg/day for 45 days). Group-3(Hypoparathyroidism): was IP injected Omeprazole (1mg/ Kg/ for each day in 45 days). Group 4: (Calcium administered group); was IP injected with Ca2+ (96mg/ Kg/ for each day in 45 days) Group 5: (Calcium + Vit.D3 administered group); was IP injected with Ca2+ (96mg/kg/day for 45 days) I/P injection and vitamin D3 (10000IU/ Kg/ for each day in 45 days) orally. Collection of blood samples were used cardiac puncture for the biochemical, hormonal assessment [Parathyroid hormone (PTH), vitamin D3, serum calcium, phosphate and magnesium. The data of results appear considerable increase in Parathyroid hormone and Ca2+ levels in hyperparathyroidism group and significantly decrease in hypoparathyroidism group as compared with control group, in addition to that significant decrease in Mg2+ concentration in hypoparathyroidism group. In conclusion in spite of the Ca2+ have a unique mechanism for absorption in rabbits, but remain the PTH essential to control Ca2+ levels.
Keywords: Calcium, Parathyroid hormone (PTH), Phosphorus, Magnesium.