Year:2022   Volume: 4   Issue: 2   Area:

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  3. ID: 143

Huda K. KHASSAF, Zainab A. SHEHAB, Fatin L. KHAPHI


Quercus is one of the species of oak found in Asian countries. This plant includes a variety of medicinal components. Tannin is the major ingredient found in around half to seventy percent of galls. The wound healing activity of a hot water extract of Quercus gall was investigated in this study. The effect of water extract of the shade-dried gall of Quercus on wound healing was investigated using incision wound models at dose level of 300 mg/kg. Our study applied on 16 male rabbits classified to 2 groups: Control group (treated by application of normal saline directly on the wound once daily), Q. extract treated group (received direct application of 300 mg/kg of extract onto the skin once a day) each group subdivided to 2 subgroup 7 and 14 days treatment each one have 4 animals. Wounds healing score, macroscopic and histologic examination were performed to determine the substantial favorable effect of the extract on wound healing. The plant showed a definite, positive effect on wound healing by showing considerable progress in healing (P < 0.05) and in characteristics such as wound healing score, the experimental group outperformed the control group. Wound healing was also improved in histopathological examinations with a significant increase in the granuloma tissue, which exhibited the capacity to improve the process of wound healing in treated rabbits with extensive re-epithelialization, collagen deposition, and cellular infiltration as comparison with non-treated group. Quercus could be a potential alternative treatment for wounds, according to this study.

Keywords: Quercus , Tannin, Wound Healing, Rabbits, incision wound.