Year:2022   Volume: 4   Issue: 2   Area:

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  3. ID: 143

Huda K. KHASSAF, Zainab A. SHEHAB, Fatin L. KHAPHI

WOUNDS MANAGEMENT AND TREATMENT EFFECT OF QUERCUS GALL

Quercus is one of the species of oak found in Asian countries. This plant includes a variety of medicinal components. Tannin is the major ingredient found in around half to seventy percent of galls. The wound healing activity of a hot water extract of Quercus gall was investigated in this study. The effect of water extract of the shade-dried gall of Quercus on wound healing was investigated using incision wound models at dose level of 300 mg/kg. Our study applied on 16 male rabbits classified to 2 groups: Control group (treated by application of normal saline directly on the wound once daily), Q. extract treated group (received direct application of 300 mg/kg of extract onto the skin once a day) each group subdivided to 2 subgroup 7 and 14 days treatment each one have 4 animals. Wounds healing score, macroscopic and histologic examination were performed to determine the substantial favorable effect of the extract on wound healing. The plant showed a definite, positive effect on wound healing by showing considerable progress in healing (P < 0.05) and in characteristics such as wound healing score, the experimental group outperformed the control group. Wound healing was also improved in histopathological examinations with a significant increase in the granuloma tissue, which exhibited the capacity to improve the process of wound healing in treated rabbits with extensive re-epithelialization, collagen deposition, and cellular infiltration as comparison with non-treated group. Quercus could be a potential alternative treatment for wounds, according to this study.

Keywords: Quercus , Tannin, Wound Healing, Rabbits, incision wound.

http://dx.doi.org/10.47832/2717-8234.11.23


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