Year:2022   Volume: 4   Issue: 3   Area:

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  3. ID: 163

Noor Khalid ZAIDAN, Wisam Mahmoud MOHAMMED, Hiba A.K.AL-HADITHE

THE EFFECT OF SULFONYLUREAS DRUGS ON KIDNEY AND LIVER FUNCTIONS IN TYPE 2 DIABETIC PATIENTS

Background: Since there is an insufficiency in both insulin secretion and insulin action, so that the treatment of patients with Type 2 diabetes is more challenging than with Type 1 diabetes. In this study we estimated the effects of treatment with sulfonylureas drug in patients with Type 2 diabetes on functions of liver and kidney. Methods: This study involved 90 individuals were divided into three groups, 30 Type 2 diabetic patients who treated with sulfonylureas drug (group 1), 30 individuals apparently healthy (group 2), as well as 30 Type 2 diabetic patients (group 3) Who diagnosed recently with Type 2 diabetes (Newly) without any treatment. Fasting serum glucose (FSG), Glycated HaemoglobinA1c (HbA1c%), liver enzymes [alanine Aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)], blood urea (BU) , serum creatinine (SCr), and total protein (TP) levels were established. Age, disease duration, and body mass index (BMI) have all been determined. Result: Sulfonylureas had a significant impact on diabetes patients' blood sugar levels, as per the study's findings, it have a significant effect on urea levels, as well as maintain liver enzyme activity at a normal level. Conclusion: This study confirmed that the medication with sulfonylureas had a beneficial effect in preserving the health of the liver for diabetic patients.

Keywords: Diabetes Type 2, Sulfonylureas, Iver Enzymes, Kidney Function.

http://dx.doi.org/10.47832/2717-8234.12.10


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