STUDY THE EFFECTS OF ANADROL OVERDOSE ON KIDNEY IN RAT MODEL
Background: Anadrol is an active androgenic anabolic steroid that has been clinically studied in numerous diseases since the 1960s. It is used in the treatment of anemia and the replacement of male sex steroids. Unfortunately, in attempts to improve physical performance, Anadrol could be misused by athletes, that can lead to poisoning contributes to renal toxicity. The Aim: This study aims to investigate nephrotoxicity of anadrol via assessment of renal injury markers and histopathological study. Materials and methods: A forty male rats, weights about (200-300 gm), aged 8-12 weeks, after acclimatization, the rats were randomly divided into four groups (n=10) : control group (in which all rats were administered normal saline (NS) via oral gavage), anadrol 10 mg/kg group (in which all rats were administered anadrol 10mg/kg via oral gavage), anadrol 20 mg/kg group (in which all rats were administered anadrol 20mg/kg via oral gavage), and anadrol 30 mg/kg group (in which all rats were administered anadrol 30mg/kg via oral gavage), the oral administration had continued for 8 weeks. At the end of study urea & creatinine were measured via chemical analysis. Then renal histopathological study was done. Results: Rats treated with anadrol displayed high level of urea & creatinine, as compared with control group. On the other hand, histopathological study exhibited significant injurious changes in the renal tissue in anadrol groups comparing with control. Conclusion: When given in high doses anadrol results in renal injury, that can be cleared via both elevated levels of renal injury markers and renal histopathological changes.
Keywords: Anadrol, Renal injury, Urea, Creatinine, Anabolic Androgenic Steroid.