STUDY THE ANTIBACTERIAL EFFECT OF NEOMYCIN SULPHATE AS SUSPENSION FORMULA FOR DIARRHOEA
Preparation of veterinary formulation as suspension contain Neomycin sulfate 5%and kaolin 1% (weight /volume) used orally to treat diarrhea caused by infected with positive or negative bacteria (Salmonella sp., E.coli, St. Aureus) and diarrheal conditions associated with many diseases including hemorrhage gastoentritis, inflammatory bowel disease. After preparation the formula which examined by bacteria like St.aureus and E.coli which found the antibacterial activity of suspension as same compared with Neomycin pure. Bacterial examination of the suspension composition was carried out using St. aurius and E.coli bacteria, in which the inhibitory capacity of the neomycin suspension was found to be close to that of pure neomycin. The initial examination of the suspension was carried out at zero time, ranging between (94-106)% and compared to pure neomycin, which ranged between (90-110)%. The stability study of suspension after storing in different temperatures (25 and 40) °C for a period of three months, where the effectiveness of the composition at a temperature of 25 °C ranged between (95- 94)%. While the efficiency of the suspension composition ranged at a temperature of (40) ºC between (95-91)% ,the activity of formula may be due to quality of the materials used. The new formula was evaluation to treat diarrhea in small animals “dog and cat” with hemorrhagic bowel infection which showed good result obtained.
Keywords: Neomycin Sulphate; Antibacterial Activity; Suspension Formula.