Year:2023   Volume: 5   Issue: 1   Area:

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  3. ID: 257

Ahlam A. AL-RIKABY, Maitham Ali AL-RIKABY

STUDY SOME PHYSIOLOGICAL ASPECTS AND HISTOPATHOLOGICAL CHANGES IN MALE RABBITS INTOXICATED BY CHLORPYRIFOS

The current experience on chlorpyrifos was undertaken to investigate the potential ‎alterations in Physiological Criteria and in liver and kidney tissues subsequent oral ‎exposure of chlorpyrifos in male rabbits . twelve of male rabbits were employed in this ‎experience, distributed into two groups randomly , group one received only corn oil ‎and served as control, whereas, while group two received CPF 33.3 mg/kg dissolved ‎with( 1ml ) corn oil daily, the exposure continued for 28 consecutive days orally. ‎outcomes of this work revealed that sub-acute oral administration of chlorpyrifos cause ‎to oxidative stress evidenced by pronounced elevation value of oxidative biomarker ‎malondialdehyde ( MDA) concomitantly with elevated in values of inflammatory ‎biomarkers ( TNF-α and CRP) and significantly reduction in total antioxidant capacity ‎‎(TAC) value, as well as this findings exhibited that chlorpyrifos administration cause to ‎marked alteration of blood indices values as well as histopathological changes were ‎observed in liver and kidney which as represented degenerative of hepatocyte, ‎dilatation and congestion in central vein, While tubular epithelial degenerations, ‎vacuolations and severe dilation in renal cortex tubules. Conclusion: we concluded from ‎findings in this study the oral exposure to CPF evoked inflammation response and ‎oxidative damage as represented by pronounced elevation in levels of CRP,TNF-alpha ‎and MDA biomarkers as well as pathohistological alterations were observably in liver ‎and kidney that indicating that chlorpyrifos elicits numerous adverse effects noteworthy ‎making it a major public health issue

Keywords: Chlorpyrifos, , CRP , TNF-Α, CBC, TAC And Oxidative Index

http://dx.doi.org/10.47832/2717-8234.14.12


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