KNOWLEDGE OF ENDOCRINE-DISRUPTING CHEMICALS DURING PREGNANCY AND FOETAL DEVELOPMENT
Endocrine-disrupting chemicals are substances that disrupt normal endocrine signaling. On the other hand, the impact of EDCs on the placenta is commonly overestimated. "Fetal growth" is controlled by a complicated mix of "maternal, placental", and foetal factors. EDCs have been linked to foetal growth retardation, thyroid abnormalities, and neurological issues in humans. Endocrine disrupting chemicals (EDCs) primarily interact with insulin, glucocorticoid, estrogenic, and thyroid pathways, resulting in epigenome and inflammatory changes that have long-term effects on normal endocrine and metabolic processes. EDCs evaluated include those present in the environment and for which human biomonitoring data are available.. This study also reveals substantial knowledge gaps that will drive future field research. International scientific organisations recommend that an inquiry be conducted and that all protective measures be implemented.
Keywords: endocrine-disrupting chemicals (EDCs); pregnancy; Growth hormone (GH) ; Human chorionic gonadotropin (HCG); attention deficit hyperactivity disorder (ADHD) ; phthalates ; estrogen receptors (ERs) ; Bi