GREEN SYNTHESIS OF NEW HYDRAZONE DERIVATIVES
Novel set of hippuric hydrazones (6-9) bearing indole and quinoline moieties were synthesized in three steps following the protocol of microwave irradiation and solvent-free conditions. The first series were synthesized by irradiate ethyl hippurate (3) with 1H-indole-6-carbaldehyde (4) under solvent-free conditions. The second series were synthesized by irradiate ethyl hippurate (3) with substituted 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (5) under solvent-free conditions. This work aims to develop new synthetic route of hippuric hydrazones which may possess a promising biological activities against covid-19. The formation of the prepared heteroaromatic hydrazones were approved by spectral 1H NMR, IR and mass data.
Keywords: Hydrazone, Microwave, Solvent-Free Conditions.