Year:2022   Volume: 4   Issue: 3   Area:

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  3. ID: 204

Harith. M. AL-AJELY

GREEN SYNTHESIS OF NEW HYDRAZONE DERIVATIVES

Novel set of hippuric hydrazones (6-9) bearing indole and quinoline moieties were synthesized in ‎three steps following the protocol of microwave irradiation and solvent-free conditions. The first ‎series were synthesized by irradiate ethyl hippurate (3) with 1H-indole-6-carbaldehyde (4) under ‎solvent-free conditions. The second series were synthesized by irradiate ethyl hippurate (3) with ‎substituted 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (5) under solvent-free conditions. This ‎work aims to develop new synthetic route of hippuric hydrazones which may possess a promising ‎biological activities against covid-19. The formation of the prepared heteroaromatic hydrazones ‎were approved by spectral 1H NMR, IR and mass data.‎

Keywords: Hydrazone, Microwave, Solvent-Free Conditions.

http://dx.doi.org/10.47832/2717-8234.12.50


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