EVALUATION THE EFFECT OF ORAL COLLAGEN-Α® SUPPLEMENTATION ON THE HEPATIC AND RENAL FUNCTIONS IN MATURE MALE RABBITS
Collagen is the main structural protein of connective tissues in animals. Comprising approximately 30% of all proteins in the body, it is present in fibrous tissues, such as tendons and ligaments, as well as in the cornea, cartilage, bones, skin, and blood vessels. This study was aims to evaluation the effect of oral administration of collagen-α® on the health status of functions of liver and kidneysin male rabbits. The animals were randomly (6 rabbits/group) divided into three groups which include: Group-A (standard group) was administered with 1 ml of distal water, Group-B (collagen-α15) was administered with 1 ml of collagen-α® and Group C (collagen –α30) was administered with 1ml of Collagen-α® for 30 days. The results showed various changes in parameters and histopathologythat related to the liver and kidneys functions in groups of collagen-α when compared with the control group. The risk of sub-acute and acute toxic effect was observed in mature male rabbit's oral administration with 1 ml collagen-α supplement for 30 days. This result suggests that the adverse effect of collagen derived supplements administration for long period.
Keywords: Collagen-Α®, Hepatic, Renal, Mature Male.